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5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one is a synthetic small molecule belonging to the thienopyrimidine class of heterocyclic compounds. It has been studied primarily as a research chemical and is not approved for clinical use in any country. The compound has been investigated for its potential as a kinase inhibitor; specifically it shows weak inhibitory activity against serine/threonine-protein kinase Chk1 (IC50 ~52 µM), but there are no known approved therapeutic indications or advanced clinical development programs for this molecule. Its primary use is in early-stage drug discovery and biochemical research as a scaffold for further medicinal chemistry optimization.[3]
- Other names
- 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
02
Targets
CHEK1 (Checkpoint kinase 1)
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